EFISIENSI RAPID ANTIGEN BERBASIS LATERAL FLOW IMMUNOASSAY (RADTs) SEBAGAI TOOL TUNGGAL DIAGNOSA COVID 19
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Nov 22, 2022
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Abstract
Pendahuluan: Penegakan penyakit covid-19 dengan benar sangat penting terkait upaya menyelamatkan pasien, serta melakukan proses skrining dan pencegahan penyebaran wabah agar tidak semakin meluas. Berbagai metode diagnose yang umum digunakan, akhir-akhir ini memang masih banyak mengalami tantangan diantaranya spesifisitas serta sensitivitas masing masing metode diagnose juga menjadi salah satu tantangan penggunaannya Tujuan : mengetahui efektifitas alat uji Covid-19 cepat berbasis antigen, untuk alat uji tunggal skrining kasus covid 19. Metode : studi literatur, terhadap 10 artikel ilmiah terkait yang disearch melalui mesin pencari google secara manual. Metode sampling adalah accidental sesuai kriteria inklusi. Untuk pengumpulan data digunakan tabel untuk mengekstrak data dari setiap penelitian, Analisa data dilakukan secara deskriptif terhadap sensitifitas dan sensitifitas rapid antigen test, disajikan dalam bentuk presentse, Hasil : Hanya2 RADTs yang memenuhi syarat WHO dengan prosentase sebesar 17% atau 2 dari 12 jenis RADTs yang digunakan dalam penelitian. Rata rata nilai sensitifitas dan spesifisitasnya adalah 66,93% dan 99,08%. Kesimpulan :Rapid Antigen Detection Technology (RADTs) sebagai tool tunggal dalam diagnosis covid 19 khususnya untuk kepentingan skrining pada populasi umum yang asimptomatik memerlukan pertimbangan matang, terkait sensitivitas beberapa produk yang masih dibawah standar sensitivitas WHO, walaupun sensitifitasnya sudah memenuhi.
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Karya ini dilisensikan di bawah Lisensi Internasional Creative Commons Attribution-NonCommercial-ShareAlike 4.0 .
How to Cite
Wahyuni, A. (2022). EFISIENSI RAPID ANTIGEN BERBASIS LATERAL FLOW IMMUNOASSAY (RADTs) SEBAGAI TOOL TUNGGAL DIAGNOSA COVID 19. Jurnal Insan Cendekia, 9(2), 173-187. https://doi.org/10.35874/jic.v9i2.1084
References
Ahmed N, Kalil MNA, Yusof W, Bakar MAA, Sjahid AS, Hassan R, Fauzi MH, Yean CY. A Performance Assessment Study of Different Clinical Samples for Rapid COVID-19 Antigen Diagnosis Tests. Diagnostics (Basel). 2022 Mar 29;12(4):847. doi: 10.3390/diagnostics12040847. PMID: 35453895; PMCID: PMC9030639.
Fernandez-Montero A, Argemi J, Rodríguez JA, Ariño AH, Moreno-Galarraga L. Validation of a rapid antigen test as a screening tool for SARS-CoV-2 infection in asymptomatic populations. Sensitivity, specificity and predictive values. EClinicalMedicine. 2021 Jul;37:100954. doi: 10.1016/j.eclinm.2021.100954. Epub 2021 Jun 9. PMID: 34127960; PMCID: PMC8189541
Ferté T, Ramel V, Cazanave C, Lafon ME, Bébéar C, Malvy D, Georges-Walryck A, Dehail P. Accuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study. J Clin Virol. 2021 Aug;141:104878. doi: 10.1016/j.jcv.2021.104878. Epub 2021 Jun 5. PMID: 34134035; PMCID: PMC8178956.
Hartantoro, D., Nuryati, A., & Nuryani, S. (2021). Uji diagnostik uji antigen sars-cov-2 pada pemeriksaan laboratorium covid-19: Studi kasus di RS Beriman Kota Balikpapan, Indonesia. PUINOVAKESMAS, 2(2), 55–61. https://doi.org/10.29238/puinova.v2i2.1171
https://ugm.ac.id/id/berita/19667-pakar-ugm-jelaskan-efektivitas-rapid-test
https://probolinggokab.go.id/akurat-tidaknya-rapid-tes-antigen-tergantung-kapan-pemeriksaannya/
https://www.kompas.com/tren/read/2020/12/19/113200065/bagaimana-akurasi-rapid-test-antigen-dibanding-tes-covid-19-lainnya-?page=all (https://www.cnnindonesia.com/teknologi/20200809142754-199-533785/mengenal-swab-antigen-covid-19-lebih-cepat-dari-tes-pcr?fbclid=IwAR1Fbzuh49yUnWWZQNTNRUPHi0ymuwzPiW1MzE8fGA6doNy5zzvfuXpmJNM
https://www.halodoc.com/artikel/rapid-test-antigen-sudah-disetujui-who-ini-faktanya
https://linksehat.com/artikel/ini-perbedaan-dan-efektivitas-rapid-test-swab-antigen-dan-pcr
https://www.healthline.com/health/how-accurate-are-rapid-covid-tests
https://ec.europa.eu/research-and-innovation/en/horizon-magazine/pcr-antigen-and-antibody-five-things-know-about-coronavirus-tests
https://www.health.govt.nz/covid-19-novel-coronavirus/covid-19-health-advice-public/covid-19-testing/covid-19-test-results-and-their-accuracy
https://www.fda.gov/medical-devices/letters-health-care-providers/potential-false-positive-results-antigen-tests-rapid-detection-sars-cov-2-letter-clinical-laboratory
https://www.mayoclinic.org/tests-procedures/covid-19-diagnostic-test/about/pac-20488900
https://www.washingtonpost.com/health/2022/01/17/rapid-coronavirus-tests-accuracy-omicron/
https://www.contagionlive.com/view/high-false-positive-rate-with-rapid-antigen-test-for-sars-cov-2-linked-to-single-batch-from-manufacturer
https://www.science.org/content/article/coronavirus-antigen-tests-quick-and-cheap-too-often-wrong
https://asm.org/Press-Releases/2021/November/Avoiding-False-Positive-for-SARS-CoV-2-When-Using
https://www.health.harvard.edu/blog/which-test-is-best-for-covid-19-2020081020734
https://www.medscape.com/viewarticle/967719
https://www.nbcnews.com/health/health-news/rapid-covid-tests-false-negatives-rcna33502
https://www.halodoc.com/artikel/ini-penjelasan-tentang-tes-antigen-bisa-positif-palsu
Jakobsen, Kathrine, Myllerup Jensen, Jakob, Todsen, Tobias, Lippert, Freddy, Martel, Cyril, Klokker, Mads, von Buchwald, Christian, 2021, Detection of SARS-CoV-2 infection by rapid antigen test in comparison with RT-PCR in a public setting, DOi - 10.1101/2021.01.22.21250042
Jeewandara C, Guruge D, Pushpakumara PD, Madhusanka D, Jayadas TT, Chaturanga IP, Aberathna IS, Danasekara S, Pathmanathan T, Jayathilaka D, Somathilaka G, Kuruppu H, Gomes L, Gunasekara V, Wijayamuni R, Ogg GS, Malavige GN. Sensitivity and specificity of two WHO approved SARS-CoV2 antigen assays in detecting patients with SARS-CoV2 infection. BMC Infect Dis. 2022 Mar 22;22(1):276. doi: 10.1186/s12879-022-07240-6. PMID: 35317731; PMCID: PMC8938642.
Møller IJB, Utke AR, Rysgaard UK, Østergaard LJ, Jespersen S. Diagnostic performance, user acceptability, and safety of unsupervised SARS-CoV-2 rapid antigen-detecting tests performed at home. Int J Infect Dis. 2022 Mar;116:358-364. doi: 10.1016/j.ijid.2022.01.019. Epub 2022 Jan 14. PMID: 35038598; PMCID: PMC8759098.
Treggiari D, Piubelli C, Caldrer S, Mistretta M, Ragusa A, Orza P, Pajola B, Piccoli D, Conti A, Lorenzi C, Serafini V, Boni M, Perandin F. SARS-CoV-2 rapid antigen test in comparison to RT-PCR targeting different genes: A real-life evaluation among unselected patients in a regional hospital of Italy. J Med Virol. 2022 Mar;94(3):1190-1195. doi: 10.1002/jmv.27378. Epub 2021 Oct 14. PMID: 34617606; PMCID: PMC8661633.
TR Randriamahazo, Andry Maharo Andrianarivelo, Andry Toky Rakotoarivo, Todisoa Mahenina Raheritiana, Luc Andriamiadana Rakotovao, Zely Arivelo Randriamanantany, Aimée Olivat Rakoto Alson, Andry Rasamindrakotroka, Evaluation of antigen-based rapid detection test for the diagnosis of SARS CoV-2 in low-income countries, 2022, Journal of Virological Methods ,Volume 300, 114409, ISSN 0166-934,https://doi.org/10.1016/j.jviromet.2021.114409.
Wahjudi, M. (2020). Kontroversi Metode Deteksi COVID-19 di Indonesia. KELUWIH: Jurnal Kesehatan Dan Kedokteran, 2(1), 32-42. https://doi.org/10.24123/kesdok.V2i1.2994
Wölfl-Duchek M, Bergmann F, Jorda A, Weber M, Müller M, Seitz T, Zoufaly A, Strassl R, Zeitlinger M, Herkner H, Schnidar H, Anderle K, Derhaschnig U. Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study. Microbiol Spectr. 2022 Feb 23;10(1):e0202921. doi: 10.1128/spectrum.02029-21. Epub 2022 Feb 2. PMID: 35107327; PMCID: PMC8809344.
Fernandez-Montero A, Argemi J, Rodríguez JA, Ariño AH, Moreno-Galarraga L. Validation of a rapid antigen test as a screening tool for SARS-CoV-2 infection in asymptomatic populations. Sensitivity, specificity and predictive values. EClinicalMedicine. 2021 Jul;37:100954. doi: 10.1016/j.eclinm.2021.100954. Epub 2021 Jun 9. PMID: 34127960; PMCID: PMC8189541
Ferté T, Ramel V, Cazanave C, Lafon ME, Bébéar C, Malvy D, Georges-Walryck A, Dehail P. Accuracy of COVID-19 rapid antigenic tests compared to RT-PCR in a student population: The StudyCov study. J Clin Virol. 2021 Aug;141:104878. doi: 10.1016/j.jcv.2021.104878. Epub 2021 Jun 5. PMID: 34134035; PMCID: PMC8178956.
Hartantoro, D., Nuryati, A., & Nuryani, S. (2021). Uji diagnostik uji antigen sars-cov-2 pada pemeriksaan laboratorium covid-19: Studi kasus di RS Beriman Kota Balikpapan, Indonesia. PUINOVAKESMAS, 2(2), 55–61. https://doi.org/10.29238/puinova.v2i2.1171
https://ugm.ac.id/id/berita/19667-pakar-ugm-jelaskan-efektivitas-rapid-test
https://probolinggokab.go.id/akurat-tidaknya-rapid-tes-antigen-tergantung-kapan-pemeriksaannya/
https://www.kompas.com/tren/read/2020/12/19/113200065/bagaimana-akurasi-rapid-test-antigen-dibanding-tes-covid-19-lainnya-?page=all (https://www.cnnindonesia.com/teknologi/20200809142754-199-533785/mengenal-swab-antigen-covid-19-lebih-cepat-dari-tes-pcr?fbclid=IwAR1Fbzuh49yUnWWZQNTNRUPHi0ymuwzPiW1MzE8fGA6doNy5zzvfuXpmJNM
https://www.halodoc.com/artikel/rapid-test-antigen-sudah-disetujui-who-ini-faktanya
https://linksehat.com/artikel/ini-perbedaan-dan-efektivitas-rapid-test-swab-antigen-dan-pcr
https://www.healthline.com/health/how-accurate-are-rapid-covid-tests
https://ec.europa.eu/research-and-innovation/en/horizon-magazine/pcr-antigen-and-antibody-five-things-know-about-coronavirus-tests
https://www.health.govt.nz/covid-19-novel-coronavirus/covid-19-health-advice-public/covid-19-testing/covid-19-test-results-and-their-accuracy
https://www.fda.gov/medical-devices/letters-health-care-providers/potential-false-positive-results-antigen-tests-rapid-detection-sars-cov-2-letter-clinical-laboratory
https://www.mayoclinic.org/tests-procedures/covid-19-diagnostic-test/about/pac-20488900
https://www.washingtonpost.com/health/2022/01/17/rapid-coronavirus-tests-accuracy-omicron/
https://www.contagionlive.com/view/high-false-positive-rate-with-rapid-antigen-test-for-sars-cov-2-linked-to-single-batch-from-manufacturer
https://www.science.org/content/article/coronavirus-antigen-tests-quick-and-cheap-too-often-wrong
https://asm.org/Press-Releases/2021/November/Avoiding-False-Positive-for-SARS-CoV-2-When-Using
https://www.health.harvard.edu/blog/which-test-is-best-for-covid-19-2020081020734
https://www.medscape.com/viewarticle/967719
https://www.nbcnews.com/health/health-news/rapid-covid-tests-false-negatives-rcna33502
https://www.halodoc.com/artikel/ini-penjelasan-tentang-tes-antigen-bisa-positif-palsu
Jakobsen, Kathrine, Myllerup Jensen, Jakob, Todsen, Tobias, Lippert, Freddy, Martel, Cyril, Klokker, Mads, von Buchwald, Christian, 2021, Detection of SARS-CoV-2 infection by rapid antigen test in comparison with RT-PCR in a public setting, DOi - 10.1101/2021.01.22.21250042
Jeewandara C, Guruge D, Pushpakumara PD, Madhusanka D, Jayadas TT, Chaturanga IP, Aberathna IS, Danasekara S, Pathmanathan T, Jayathilaka D, Somathilaka G, Kuruppu H, Gomes L, Gunasekara V, Wijayamuni R, Ogg GS, Malavige GN. Sensitivity and specificity of two WHO approved SARS-CoV2 antigen assays in detecting patients with SARS-CoV2 infection. BMC Infect Dis. 2022 Mar 22;22(1):276. doi: 10.1186/s12879-022-07240-6. PMID: 35317731; PMCID: PMC8938642.
Møller IJB, Utke AR, Rysgaard UK, Østergaard LJ, Jespersen S. Diagnostic performance, user acceptability, and safety of unsupervised SARS-CoV-2 rapid antigen-detecting tests performed at home. Int J Infect Dis. 2022 Mar;116:358-364. doi: 10.1016/j.ijid.2022.01.019. Epub 2022 Jan 14. PMID: 35038598; PMCID: PMC8759098.
Treggiari D, Piubelli C, Caldrer S, Mistretta M, Ragusa A, Orza P, Pajola B, Piccoli D, Conti A, Lorenzi C, Serafini V, Boni M, Perandin F. SARS-CoV-2 rapid antigen test in comparison to RT-PCR targeting different genes: A real-life evaluation among unselected patients in a regional hospital of Italy. J Med Virol. 2022 Mar;94(3):1190-1195. doi: 10.1002/jmv.27378. Epub 2021 Oct 14. PMID: 34617606; PMCID: PMC8661633.
TR Randriamahazo, Andry Maharo Andrianarivelo, Andry Toky Rakotoarivo, Todisoa Mahenina Raheritiana, Luc Andriamiadana Rakotovao, Zely Arivelo Randriamanantany, Aimée Olivat Rakoto Alson, Andry Rasamindrakotroka, Evaluation of antigen-based rapid detection test for the diagnosis of SARS CoV-2 in low-income countries, 2022, Journal of Virological Methods ,Volume 300, 114409, ISSN 0166-934,https://doi.org/10.1016/j.jviromet.2021.114409.
Wahjudi, M. (2020). Kontroversi Metode Deteksi COVID-19 di Indonesia. KELUWIH: Jurnal Kesehatan Dan Kedokteran, 2(1), 32-42. https://doi.org/10.24123/kesdok.V2i1.2994
Wölfl-Duchek M, Bergmann F, Jorda A, Weber M, Müller M, Seitz T, Zoufaly A, Strassl R, Zeitlinger M, Herkner H, Schnidar H, Anderle K, Derhaschnig U. Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Detection Tests Using Oral, Anterior Nasal, and Nasopharyngeal Swabs: a Diagnostic Accuracy Study. Microbiol Spectr. 2022 Feb 23;10(1):e0202921. doi: 10.1128/spectrum.02029-21. Epub 2022 Feb 2. PMID: 35107327; PMCID: PMC8809344.