BAKTERI PENYEBAB BAKTEREMIA DAN POLA RESISTENSI TERHADAP ANTIBIOTIK PADA KULTUR DARAH
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Sep 27, 2023
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Abstract
Pendahuluan: Bakteremia adalah kondisi ditemukannya bakteri pada aliran darah. Angka kejadian kasus infeksi bakteremia pada anak dilaporkan cukup tinggi, sehingga sangat penting untuk segera melakukan diagnosis bakteremia pada anak-anak. Tujuan: Penelitian ini bertujuan untuk mengetahui bakteri penyebab bakteremia dan antibiotik yang paling resisten serta sensitif pada bakteri tersebut. Metode: Metode yang digunakan dalam penelitian ini adalah penelitian deskriptif. Data yang digunakan adalah data sekunder dengan menggunakan teknik pengumpulan purposive sampling. Data sekunder yang digunakan adalah hasil pemeriksaan kultur darah di Laboratorium Klinik Prodia Denpasar Tahun 2021-2022. Hasil: Hasil penelitian ditemukan bahwa penyebab bakteremia yaitu Acinetobacter baumanii (23.88%) Klebsiella pneumoniae (23.88%) Escherichia coli (20.90%) Staphylococcus haemolitycus (16.42%) Stapylococcus hominis (14.92%). Antibiotik paling resisten dari Acinetobater baumanii adalah Piperacillin-Tazobaktam dan Ciprofloxacin (68.8%) dan antibiotik yang paling sensitif adalah Trimethoprim-Sulfamethoxazole (93.7%). Seluruh (100%) isolat Klebsiella pneumoniae resisten terhadap Ampicilin dan paling sensitive terhadap Ertapenem (100%). Kesimpulan: Dari hasil yang didapat, dapat ditarik kesimpulan bahwa Acinetobacter baumanii dan Klebsiella pneumoniae merupakan bakteri yang paling menyebabkan bakteremia dan sebagain besar isolat bakteri telah mengalami Multi Drug Resisten.
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How to Cite
Premandari, I. G. A. A. W., Abadi, M., & Arwidiana, D. (2023). BAKTERI PENYEBAB BAKTEREMIA DAN POLA RESISTENSI TERHADAP ANTIBIOTIK PADA KULTUR DARAH. Jurnal Insan Cendekia, 10(3), 189-200. https://doi.org/10.35874/jic.v10i3.1239
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Lebinson, Purba David, (2021). Skripsi Sarjana [1526]: Profil Bakteri Penyebab Bakteremia dan Pola Kepekaan terhadap Antibiotik serta Faktor Risikonya di RSUP H. Adam Malik Medan Tahun 2020. Repositori Institusi Universitas Sumatera Utara
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Christaki, Eirini & Bourboulis, Evangelos J Giamarellos. (2014). The Complex Pathogenesis of Bacteremia From Antimicrobial Clearance Mechanisms to the Genetic Background of the Host. virulence 5:1, 57–65; January 1, 2014; © 2014 Landes Bioscience.
Chopra, Teena., et al.,(2013). Epidemiology of Bloodstream Infections Caused by Acinetobacter baumannii and Impact of Drug Resistance to both Carbapenems and Ampicillin-Sulbactam on Clinical Outcomes. Antimicrob Agents Chemother. 2013 Dec; 57(12): 6270–6275. doi: 10.1128/AAC.01520-13/. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837851/
Fowoyo, P, T., Ogunbanwo, S.T. (2017) Antimicrobial resistance in coagulase-negative staphylococci from Nigerian traditional fermented foods. Ann Clin Microbiol Antimicrob. 2017; 16: 4. Published online 2017 Jan 31. doi: 10.1186/s12941-017-0181-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282922/
Ihsan,Syarifaha. (2020) Evaluasi Pola Kepekaan Isolat Avinetobacter baumanii Terhadap Beberapa golongan antibiotik di Laboratorium Mikrobiologi Klinik FKUI-RSCMTahun 2013-2019. SKRIPSI.FKUI. 2020. https://library.fk.ui.ac.id/?p=show_detail&id=26550
Karina, Karina, et al. (2015). Pola Resistensi Staphylococcus Koagulase Negatif Terhadap Antibiotik Yang Diisolasi Dari Kultur Darah Neonatus Tersangka Sepsis Di Instalasi Perawatan Neonatus RSUD Arifin Achmad Provinsi Riau Periode 01 Januari-31 Desember 2014. Jurnal Online Mahasiswa Fakultas Kedokteran Universitas Riau, vol. 2, no. 2, Oct. 2015, pp. 1-9.
Katzung B G., (2018). Basic Clinical Pharmacology. 14th Ed. North America : Mc Graw Education. 2018. P. 2-8, 640-645
Kemenkes RI.(2017). Pedoman Nasional Pelayanan TataLaksana Sepsis. Jakarta: Kemenkes RI.
Kemnic, Tyler R & Coleman, Meghan. (2022). Trimethoprim Sulfamethoxazole. Treasure Island (FL): StatPearls Publishing; 2023 Jan. https://www.ncbi.nlm.nih.gov/books/NBK513232/
Kobayashi, Tatsuya.,et al.(2021). Clinical and Microbiological Characteristics of Recurrent Escherichia coli Bacteremia. Microbiol Spectr. 2021 Nov-Dec; 9(3): e01399-21. Published online 2021 Dec 8. doi: 10.1128/Spectrum.01399-21
Lebinson, Purba David, (2021). Skripsi Sarjana [1526]: Profil Bakteri Penyebab Bakteremia dan Pola Kepekaan terhadap Antibiotik serta Faktor Risikonya di RSUP H. Adam Malik Medan Tahun 2020. Repositori Institusi Universitas Sumatera Utara
Milanda,Tiana. Saragih, C.Bonar. Kusuma, Sri A F.(2014). Deteksi Gen Resistensi Ampisilin (bla) pada Escherichia coli Isolat Klinik dengan Metode Polymerase Chain Reaction. Jurnal Farmasi Klinik Indonesia.Vol 3, No 3 (2014). https://jurnal.unpad.ac.id/ijcp/article/view/12836
Patel, Shivali., et al.(2023). Vancomycin. Treasure Island (FL): StatPearls Publishing;2023. https://www.ncbi.nlm.nih.gov/books/NBK459263/
Peechakara, Basil V., Basit, Hajira., Gupta Mohit. (2022). Ampicillin. 2022 Aug 31. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–.PMID: 30137853
Sader, Helio S., Carvalhaes, Cecilia G., et al, (2021). Antimicrobial activity of dalbavancin against clinical isolates of coagulase-negative staphylococci from the USA and Europe stratified by species. Journal of Global Antimicrobial Resistance. Volume 24, March 2021, Pages 48-52. https://doi.org/10.1016/j.jgar.2020.11.020
Tariq, Mahmud Tariq., (2014). Bacteriologic profile and antibiogram of blood culture isolates from a children's hospital in Kabul. J Coll Physicians Surg Pak. 2016. PMID: 27981921. https://pubmed.ncbi.nlm.nih.gov/24953929/
Vrancianu, C.O.; Gheorghe, I.; Czobor, I.B.; Chifiriuc, M.C. (2020) Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii. Microorganisms 2020, 8, 935. https://doi.org/10.3390/microorganisms8060935