HUBUNGAN RASIO CD4/CD8 DENGAN RASIO NEUTROFIL/LIMFOSIT PADA PASIEN TERINFEKSI HIV YANG MENDAPAT TERAPI ANTIRETROVIRAL (ARV)
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Oct 1, 2025
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Abstract
Pendahuluan: Salah satu masalah kesehatan utama di dunia dengan angka kematian yang tinggi adalah HIV/AIDS. Pengobatan antiretroviral (ARV) dapat menghentikan penularan HIV/AIDS dengan cepat, sehingga mengurangi epidemi di masyarakat. Namun, terapi ARV jangka panjang menyebabkan peningkatan sel CD8 secara bertahap dan penurunan rasio CD4/CD8, yang memengaruhi peradangan non-AIDS sebagaimana diukur dengan uji Rasio Neutrofil/Limfosit (NLR). Tujuan: penelitian ini adalah untuk menyelidiki hubungan antara NLR dan Rasio CD4/CD8 pada individu HIV-positif yang menjalani pengobatan antiretroviral (ARV). Metode: Penelitian ini menggunakan desain cross-sectional dan analisis observasional. Perangkat lunak SPSS digunakan untuk menguji 62 sampel penelitian yang berasal dari data sekunder. Hasil: Rata-rata hasil pemeriksaan Rasio Neutrofil/Limfosit pada 62 data yang diperiksa adalah 1.5768 dengan interpretasi normal. Rata-rata hasil pemeriksaan Rasio CD4/CD8 adalah 0,5310 dengan interpretasi rendah. Hasil korelasi Pearson Product Moment menunjukkan adanya hubungan antara Rasio CD4/CD8 dan Rasio Neutrofil/Limfosit dengan nilai sig. 0,030 (<0,05). Kesimpulan: Terdapat korelasi negatif yang lemah antara variabel; semakin tinggi Rasio Neutrofil/Limfosit, semakin rendah Rasio CD4/CD8. Saran: Kelainan kuantitatif dan fungsional pada CD8 akan tetap ada bahkan setelah ARV secara efektif menghambat virus dan memulihkan CD4, oleh karena itu diperlukan pemantauan terapi yang tepat.
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Karya ini dilisensikan di bawah Lisensi Internasional Creative Commons Attribution-NonCommercial-ShareAlike 4.0 .
How to Cite
Purwanti, N. W. N., Yanti, N. L., & Cahyani, A. A. (2025). HUBUNGAN RASIO CD4/CD8 DENGAN RASIO NEUTROFIL/LIMFOSIT PADA PASIEN TERINFEKSI HIV YANG MENDAPAT TERAPI ANTIRETROVIRAL (ARV). Jurnal Insan Cendekia, 12(2), 109-118. https://doi.org/10.35874/jic.v12i2.1482
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Deng, L., Si, Y., Wu, Q., Cao, Y., Lian, S., & Li, L., 2023, ‘Higher Neutrophil-to-Lymphocyte Ratio (NLR) Is a Preoperative Inflammation Biomarker of Poor Prognosis in HIV-Infected Patients with Colorectal Cancer: A Retrospective Study’, Canadian Journal of Gastroenterology and Hepatology, 2023. https://doi.org/10.1155/2023/7966625.
Dewi, R. S., 2022, ‘Profil Penggunaan ARV dan Nilai CD4 pada Pasien HIV/AIDS di RS X Pekanbaru’. Jurnal Ilmiah Farmasi Farmasyifa 5, no. 1 (Januari): 71-78.
Fauzi, S. A., Wardani, H. P., & Triyani, Y., 2021, ‘Scoping Review: Peran Rasio Neutrofil-Limfosit sebagai Biomarker pada Pasien HIV dengan Komorbid atau Tanpa Komorbid’
Hanberg, J. S., Freiberg, M. S., Goetz, M. B., Rodriguez-Barradas, M. C., Gibert, C., Oursler, K. A., Justice, A. C., & Tate, J. P., 2019, ‘Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios as Prognostic Inflammatory Biomarkers in Human Immunodeficiency Virus (HIV), Hepatitis C Virus (HCV), and HIV/HCV Coinfection’, Open Forum Infectious Diseases, 6(10), 1–9. https://doi.org/10.1093/ofid/ofz347.
Handayani, Kartika, 2021, ‘Hubungan Antara Jumlah CD4 dengan Kadar Rasio Neurofil-Limfosit (NLR) pada Pasien Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS)’, [Tesis, Program Pendidikan Dokter Spesialis-1 (Sp.1) Departemen Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Hasanuddin Makassar].
Hattab, Suhaib., Amelia Guihot, Marguirite Guiguet, Slim Fourati, Guislaine Carcelain, Febienne Caby, Anne-Genevieve Marcelin, Brigitte Autran, Dominique Costagliola, & Christine Katlama, 2014, ‘Comparative Impact of Antiretroviral Drugs on Markers of Inflammation and Immune Activation During the First Two Years of Effective Therapy for HIV-1 Infection: An Observational Study’, BMC Infectious Disease, 14: 122. http://www.biomedcentral.com/1471-2334/14/122.
Jaenab, Sulistyaningsih Prabawati, Rista Novitasari, &Setyo R. Wulandari, 2021, ‘Tingkat Pengetahuan Remaja tentang HIV/AIDS di SMA Negeri 10 Yogyakarta’, Jurnal Kesehatan 12, No. 1 (Agustus): 337-342. http://dx.doi.org/10.35730/jk.v12i0.510.
Kurniawati, Ifa, 2021, ‘Hitung Jumlah Sel CD4, CD8 dan Rasio Antara CD4 dan CD8 pada Pasien HIV/AIDS dengan Koinfeksi Tuberkulosis (Studi Pustaka)’.
Mardalena, M., & Apriani, S., 2020, ‘Membangun Perilaku Anti Acquired Immune Deficiency Syndrome (AIDS)-Human Immunodeficiency Virus (HIV) Pada Kelompok Remaja’, BERDIKARI: Jurnal Inovasi Dan Penerapan Ipteks, 8(1). https://doi.org/10.18196/bdr.8175.
Martínez-Sanz, J., Díaz-Álvarez, J., Rosas, M., Ron, R., Iribarren, J. A., Bernal, E., Gutiérrez, F., Ruiz Sancho, A., Cabello, N., Olalla, J., Moreno, S., Serrano-Villar, S., Jarrín, I., Dalmau, D., Navarro, M. L., González, M. I., Garcia, F., Poveda, E., Iribarren, J. A., … Telleria, P, 2023, ‘Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS events’, EBioMedicine, 95. https://doi.org/10.1016/j.ebiom.2023.104773.
McBride, J. A., & Striker, R., 2017, ‘Imbalance in the game of T cells: What can the CD4/CD8 T-cell ratio tell us about HIV and health?’, PLoS Pathogens, 13(11). https://doi.org/10.1371/journal.ppat.1006624.
Mudd, J. C., & Lederman, M. M, 2014, ‘CD8 T cell persistence in treated HIV infection’, In Current Opinion in HIV and AIDS (Vol. 9, Issue 5, pp. 500–505). Lippincott Williams and Wilkins. https://doi.org/10.1097/COH.0000000000000086.
NIH Office of AIDS Research Advisory Council 2024, ‘Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV How to Cite the Adult and Adolescent Antiretroviral Guidelines: Panel on Antiretroviral Guidelines for Adults and Adolescents’, Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. https://clinicalinfo.hiv.gov/.
Raffetti, E., Donato, F., Casari, S., Castelnuovo, F., Sighinolfi, L., Bandera, A., Maggiolo, F., Ladisa, N., di Pietro, M., Fornabaio, C., Digiambenedetto, S., & Quiros-Roldan, E. 2017, ‘Systemic inflammation-based scores and mortality for all causes in HIV-infected patients: A MASTER cohort study’, BMC Infectious Diseases, 17(1). https://doi.org/10.1186/s12879-017-2280-5.
Raharjo, Sahid 2020, ‘Cara Melakukan Analisis Korelasi Bivariat Pearson dengan SPSS’, Universitas Esa Unggul.
Ron, Raquel, Elena Morena, Javier Martinez-Sanz, Fatima Branas, Talia Sainz, Santiago Moreno, &Sergio Serrano-Villar 2023, ‘CD4/CD8 Ratio During Human Immunodeficiency Virus Treatment. Time for Routine Monitoring’, Clinical Infectious Disease: an official publication of the infectious disease society of America. 76, no. 9 (May): 1688-1696.
Sari, Novi Kurnia, 2019, ‘Hubungan Rasio CD4/CD8 dan Laju Endap Darah terhadap Kualitas Hidup Pasien HIV/AIDS di RS Dr. Moewardi Surakarta’, https://digilib.uns.ac.id/dokumen/abstrak/82431/Hubungan-Rasio-Cd4Cd8-dan-Laju-Endap-Darah-Terhadap-Kualitas-Hidup-Pasien-HIVAIDS-di-RS-Dr-Moewardi-Surakarta-2019#:~:text=Rasio%20CD4/CD8%20yang%20rendah%20dihubungkan%20dengan%20aktivasi,telah%20dihubungkan%20dengan%20suatu%20prognosis%20yang%20buruk.
SIHA Dinkes 2022, ‘Laporan Eksekutif Perkembangan HIV AIDS dan Infeksi Menular Seksual (IMS) Triwulan I Tahun 2022’
Siraj, J., Feyissa, D., Mamo, Y., Zewudie, A., Regesa, T., Ejeta, F., Feyisa, D., Hasen, G., Mohammed, T., & Aferu, T. 2021, ‘Antiretroviral treatment failure and associated factors among HIV patients on the first-line antiretroviral therapy at Mizan-Tepi University Teaching Hospital Southwest Ethiopia: A cross-sectional study’, Medicine (United States), 100(51), E28357. https://doi.org/10.1097/MD.0000000000028357
Subhaktiyasa, Putu Gede 2024, ‘Menentukan Populasi dan Sampel: Pendekatan Metodologi Penelitian Kuantitatif dan Kualitatif’, Jurnal Ilmiah Profesi Pendidikan Volume 9 No. 4 (November).
Suhartini, A., Nina M., Eem H., Adang D. 2024, ‘Hubungan Viral Load terhadap Neutrophil Lymphocyte Ratio (NLR) dan Limfosit T CD4+ pada Orang dengan HIV/AIDS (ODHA)’, Jurnal Kesehatan Siliwangi Vol. 4 No. 3.
Susanto, Shintasari. Umi S. Intansari, &Teguh Triyono 2019, ‘Rasio Sel T CD4/CD8 Pra dan Enam Bulan Pasca Terapi Anti-Retroviral pada Pasien Terinfeksi Human Immunodeficiency Virus’, Universitas Gadjah Mada.
Susmiati, Indah Jayani 2019, ‘Fenomena Penyebaran HIV/AIDS Pasca Penutupan Lokalisasi Semampir di Kota Kediri’, Jurnal Ilmu Kesehatan 7, no. 2 (Mei): 290-294.
Tiffany, E., Yuniartika, W., 2023, ‘Efektifitas Terapi Antiretroviral Terhadap Pasien HIV (Literature Review)’, In Jurnal Multidisiplin West Science (Vol. 02, Issue 05). Mei.
Triyani, Irma., Mather, R. Virdiyanti 2025, ‘Faktor-Faktor yang Mempengaruhi Keberhasilan Terapi Antiretroviral pada Pasien HIV/AIDS’, Scientific Journal of Nursing Research Vol. 7 No.1 2025, hlm 13-18.